Activin effects on follicular growth in <i>in vitro</i> preantral follicle culture

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The Effects of Fibroblast Co-Culture and Activin A on in vitro Growth of Mouse Preantral Follicles

Background: This study was conducted to evaluate fibroblast co-culture and Activin A on in vitro maturation and fertilization of mouse preantral follicles. Methods: The ovaries from 12-14-day-old mice were dissected, and 120-150 μm preantral follicles were cultured individually in α-MEM as based medium for 12 days. A total number of 456 follicles were cultured in four conditions: (i) base mediu...

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An in vitro Comparative Study of Follicle Stimulating Hormone (FSH) and Activin A Effects on the Maturation of Preantral Follicle-Enclosed Oocytes from Immature Syrian Mice

Objectives: It was aimed to investigate the effects of different doses of follicle stimulating hormone (FSH) and activin A on the growth and maturation of preantral mouse follicles during the in vitro culture. Methods: Preantral follicles (90-100 µm in diameter) were harvested from 6-8 week-old Syrian mice and cultured in TCM199 culture medium for 6 days to see the effect of FSH and Activin A...

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Effects of growth hormone, activin, and follistatin on the development of preantral follicle from immature female mice.

The aim of this study was to investigate whether GH and insulin-like growth factor I (IGF-I) are involved in preantral folliculogenesis and, if so, to clarify the relationship between GH/IGF-I and activin/follistatin (FS) systems in immature female mice. Ovaries were obtained from 11-day-old mice, and preantral follicles, 100-105 microm in diameter, were mechanically isolated and selected for c...

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Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis.

The transition from preantral to early antral stage is the penultimate stage of ovarian follicular development in terms of gonadotropin dependence and follicle destiny. Although oocyte-somatic cell communication is important in early follicular development, our knowledge of the precise role of the oocyte-derived growth differentiation factor (GDF)-9 during preantral follicle growth is incomplet...

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The effects of fibroblast co-culture and activin A on in vitro growth of mouse preantral follicles.

BACKGROUND This study was conducted to evaluate fibroblast co-culture and Activin A on in vitro maturation and fertilization of mouse preantral follicles. METHODS The ovaries from 12-14-day-old mice were dissected, and 120-150 μm preantral follicles were cultured individually in α-MEM as based medium for 12 days. A total number of 456 follicles were cultured in four conditions: (i) base mediu...

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ژورنال

عنوان ژورنال: The Journal of Medical Investigation

سال: 2019

ISSN: 1343-1420,1349-6867

DOI: 10.2152/jmi.66.165